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How GLP-1 Affects the Brain The most profound effects of GLP-1, particularly concerning weight loss, stem from its ability to trick the brain
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Risk of bias summary
These medications carry a boxed warning about thyroid C-cell tumors (contraindicated with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings about potential risks including pancreatitis, gallbladder disease, acute kidney injury with dehydration, and worsening diabetic retinopathy with rapid glucose reduction (particularly with semaglutide)
While branded GLP-1 medications often have specific criteriasuch as a BMI of 30 or higher, or 27 with weight-related health conditionscompounded medications allow greater flexibility
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