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The ROS-mediated damage is further enhanced in older individuals since during aging, GSH levels appear to diminish in numerous tissues, thereby placing cells at increased risk of stress-related death (Maher, 2005)
Additionally, glutathione protects the skin from oxidative stress caused by environmental factors such as sun exposure and pollution
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The roles of CBS and CSE in neoangiogenesis have been shown for different cancer types, and possibly involve per-sulphidation of KATP channels and the activation of MAPK signalling pathways, 156,157,158,159,160 which have been demonstrated in endothelial cells
