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Acknowledgements We thank members of the Cryo-electron Microscopy and Tomography Center of St Jude Childrens Research Hospital for help with cryo-EM data collection

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Your clinician will consider factors including: Your overall health status and comorbidities The degree of obesity and associated health risks Previous history of biliary symptoms The urgency of weight loss for other medical conditions In some cases, particularly where obesity poses immediate health risks (such as severe type 2 diabetes or cardiovascular disease), the benefits of weight loss may outweigh the potential gallstone risks

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