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OH), H 2 O 2 , nitrogen dioxide (NO) and peroxynitrite (ONOO ), these deriving mainly from the mitochondrial electron transport chain, changes in metal valence states and enzymatic processes (e.g., MAO-B, NADPH oxidase) (45)
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Filomeni and Ciriolo, 2006), and downstream targets (mitochondrial and cytoskeleton proteins)
Thiol groups displayed on the cell surface proteins have also been shown to maintain a reducing microenvironment and help in the oxidative stress protection of Lc