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However, when these cellular defenses become overwhelmed by chronic inflammation, viral persistence, or environmental triggers, they can create symptoms throughout the entire body

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We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study