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The presence of comorbidities can significantly impact the pharmacokinetics of Vitamin B12, making it essential to adjust dosing protocols. Expert Opinion on Vitamin B12 Therapy Genetic Factors Affecting B12 Metabolism Genetics play a role in how well someone can use Vitamin B12
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Beedholm-Ebsen, R
Castle later labeled the essential substance secreted by a normal stomach as intrinsic factor and the substance present in food as extrinsic factor. Subsequent studies showed that the intrinsic factor serves as an intestinal transport vehicle for the extrinsic factor (later identified as vitamin B12) (139)
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