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These wide-ranging effects explain why glutathione depletion has been associated with accelerated aging, increased disease susceptibility, impaired detoxification capacity, and compromised immune responses

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After incubation on ice for 1 h, the homogenates were centrifuged at 20,400 g for 20 min at 4 C, and the resulting supernatants were appropriately diluted and used in the assays

Yeh C-T, Ching L-C, Yen G-C

In summary, our study identifies a genetic regulator of hepatic SAA metabolism and a key determinant of sensitivity to methionine restriction and chemotherapy in liver cancer

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