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Step 4: Preparation of compound of formula-13 The reaction mixture obtained in step 3 was slowly added to a mixture of ethanol (850 ml), DIPEA (64 ml) and 2-(2-(2-aminoethoxy)ethoxy)acetic acid compound of formula- 10 (50 gm) at 25-30C and stirred the obtained reaction mixture for 45 min at the same temperature

And 5-Amino-1MQ addresses NNMT overexpression to reactivate fat cell metabolism

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However, when balanced with GLP-1 and GIP activation, the net metabolic effect may favour fat oxidation and weight reduction

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The clinical trial data for Contrave are more impressive than those for bupropion alone