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Any amount ingested by a nursing infant would face enzymatic degradation in the gut

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1,6,7 Options include SGLT-2 inhibitors, which also have cardiorenal protective benefits, or sulfonylureas

Despite promising preclinical studies, a 12-week clinical trial using an iteration of this initial dual-incretin agonist failed to demonstrate superiority relative to a GLP-1R monoagonist 15 , raising questions about multi-receptor strategies in humans