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Indeed, based on evidence from GST activity and RNAi studies, three GSTs are thought to have contributed to the adaptation of N
The risk of metformin accumulation and the development of lactic acidosis increases in proportion to the degree of impaired renal function, therefore, the drug should not be prescribed to patients with a serum creatinine concentration above the upper age limit of the norm
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Rev Physiol Biochem Pharmacol 175:71102 Lyu H, Wang H, Li L et al (2020) Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses
