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While multiple clinical trials and population-based studies have established the safety profile of GLP-1RAs, continued vigilance regarding the association between GLP-1RA therapy and pancreatic cancer risk remains imperative in clinical practice, given the potential for low-grade chronic pancreatitis to induce pancreatic cancer
More severe reactions, like a large rash, hives, or swelling should be discussed with your doctor
Egbunike, G
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With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health