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Real-world data from healthcare databases have occasionally shown small increases in pancreatitis incidence, though these findings may reflect confounding factors such as obesity severity, rapid weight loss, or pre-existing pancreatic disease

However, this combination requires careful medical oversight to optimize dosing and minimize the risk of side effects, especially hypoglycemia (low blood sugar), which can be more likely when these medications are used together

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And the answer is not as simple as yes or no

Retatrutide has been associated with increases in resting heart rate in clinical trials