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Researchers often seek information about side effects because understanding the safety profile of any compound is an important part of scientific evaluation

For perspective, Denver, famously dubbed the Mile-High City at 5,280 feet, sees approximately 10% of visitors experiencing altitude sicknessdespite its elevation being slightly lower than Sun Valley

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Incapsula incident ID: 197000260374894425-29379736686102177

This review integrates preclinical research related to the effects of both stress and antidepressant treatment on synaptic plasticity, and proposes normalization of synaptic function as a final common pathway for depression treatment

Evidence tier: theoretical safety concern, unstudied in humans