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[29, 30, 31] Risk factors: Diabetes (especially in combination with SGLT2 inhibitors use) Reduced oral intake and severe GI symptoms Dehydration Presentation: Nausea, vomiting, abdominal pain Anion gap metabolic acidosis Elevated ketones Normal or mildly elevated glucose Key point: EDKA has not been observed in non-diabetic patients in large cohort data

The exact timing depends on your specific medication, injection or oral format, and the type of surgery scheduled

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Pathway 3: Pharmacodynamic Insulin-Glucose Interactions Triple agonists potentiate the glucose-lowering effect of all insulin secretagogues and exogenous insulin

Neither BPC-157 or TB-500, the two compounds in REGEN, are approved by Health Canada