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As with berberine, transdermal chromium delivery has not been extensively studied compared to oral supplementation

Despite substantial progress, the successful development of peptides as drugs still requires a number of limitations to be addressed, including short in vivo half-lives and poor membrane permeability

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Eventually, the animals were sacrificed by sodium thiopental intraperitoneally (100 mg/kg) [26] and then the kidney tissues were removed

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In brief, the mice were administered a daily topical application of 62.5 mg of 5% imiquimod cream (Mingxinlidi, Sichuan, China) on their shaved backs for seven consecutive days