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Doi:10.2174/1381612824666180515125918 Chang CH, Tsai WC, Lin MS, et al

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Supplementary Validation Method: LCMS/MS For high-sensitivity detection requirements, liquid chromatographytandem mass spectrometry is used for supplementary validation, especially suitable for trace component analysis and metabolic studies

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Neither option is universally "better." Many laboratories routinely use BAC water because its preservative supports repeated handling, while certain experimental protocols specifically require preservative-free sterile water