They're feeling better because of all of these impacts on the body that are independent of the weight loss
Patients should seek prompt medical attention if they experience symptoms that may indicate worsening liver disease or a serious complication, including: Persistent fatigue or unexplained weight loss Yellowing of the skin or whites of the eyes (jaundice) Itching (pruritus), dark urine, or pale stools Swelling of the abdomen (ascites) Confusion or excessive drowsiness Vomiting blood or passing black, tarry stools Severe or persistent abdominal pain These symptoms require urgent clinical assessment
Of note, in STEP 3 intensive behavioral treatment was also administered in both arms, and in STEP 4 all patients were initially assigned to semaglutide 2.4 mg but were randomized 2:1 to semaglutide 2.4 or placebo after 20 weeks 25
Longitudinal analysis reveals high prevalence of EpsteinBarr virus associated with multiple sclerosis
These might seem superficial concerns, but for people who have spent years avoiding mirrors and cameras, they carry significant psychological weight
This is the central limitation of the evidence base, and any honest discussion has to start there