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Acknowledgements The authors thank Professor Genji Qin (Peking University, China) for providing the vps29 mutant and Professor Ruixi Li (South University of Science and Technology, China) and Professor Caiji Gao (South China Normal University, China) for providing the snx1/snx2a/snx2b mutant

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Finally, the fact that normal ducts, ductal pancreatic carcinomas, or PanIN 3 do not express GLP1R indicate that GLP1Rs are unlikely to be related to neoplastic transformation in the pancreas

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