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Maximum: 14 mg once daily, if 7 mg dose is insufficient Possible side effects include: Gastrointestinal: nausea, vomiting, diarrhea The long-term safety of GLP-1 receptor agonists has not yet been established
Seek immediate medical attention if you have difficulty swallowing or experience signs of an allergic reaction, such as: trouble breathing or swallowing, rashes, itching, blistered skin or swelling of your mouth, face, tongue or throat
Healthcare providers may avoid prescribing topiramate for individuals with a history of: Suicidal thoughts or behaviors Kidney stones Metabolic acidosis Bone conditions like osteopenia, osteomalacia, or osteoporosis Glaucoma Respiratory issues like asthma or COPD Depression or mood disorders Growth problems Thyroid, liver, or kidney disease Because topiramate can increase the risk of kidney stones, its important to stay well-hydrated while taking the medication
BCBS of Massachusetts will tighten GLP-1 drug coverage starting next year
The number needed to treat to prevent one major adverse cardiovascular event after one and three years of use was 378 and 131, respectively
Gastrointestinal side effects: GLP-1-based agents, including retatrutide, commonly cause nausea, vomiting, diarrhoea, and reduced appetite, partly through slowing of gastric emptying
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