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Can doses be spaced out
The most promising compounds, 39 and 40 (Figure 6), showed an IC 50 of 2.80 nM against DPP-4 catalytic activity, with 20 - 40-fold selectivity over the DPP-8 and DPP-9 isozymes
Semaglutide is also contraindicated in patients with a prior serious hypersensitivity reaction to the medication or its components
Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
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