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Based on the patients response and tolerability, the dose can increase in steps up to 15 mg weekly
Pollak, 2008)
Gradually increase by 0.1 mg every 4 weeks until reaching the effective dose
10.1097/prs.0000000000000268 77 MehraraB
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A tissue microarrays containing a total of 204 metastatic melanomas (71 lymph nodes, 55 skin, 33 brain, 15 lung, 14 small bowel, 6 liver, 4 parotid, 2 bone, 2 nasal sinus, 1 breast, and 1 spleen) from the same number of patients were collected from the Department of Pathology at La Timone Hospital (Marseille, France)
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