Some researchers posit that this effect occurs via an intrinsic mechanism, while others hypothesize that it may be mediated through the paracrine actions of insulin or somatostatin
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Lastly, it is notable that the liquid medium routinely used for induction of gliotoxin biosynthesis (i.e., Czapek-Dox) provides a zinc-limiting culture condition (Saleh et al., 2018), which strongly suggests that zinc starvation could be the primary stimulus that triggers the ZafA-mediated induction of gliZ expression and, hence, gliotoxin biosynthesis, whereas the function of GliZ would be dedicated to maintain steady expression levels of the gli genes and gliotoxin biosynthesis while zinc starvation persists
Can glutathione improve my overall health
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Hultman American Journal of Physiology-Endocrinology and Metabolism 1994 266:5, E725-E730 Baker JS, McCormick MC, Robergs RA
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