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PLoS ONE (2008) 3:e3974

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This study enrolled adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity

Excess body fat can disrupt hormone balance by converting testosterone into estrogen, lowering sperm count, and increasing inflammation a condition sometimes referred to as obesity-related hypogonadism

Our findings highlight the importance of heme in artemisinin activation and the role of oxidative stress in drug efficacy