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Additionally, administration of GLP-3R was associated with improvements in five of the eight domains of the Short Form-36 health survey as well as in the physical component summary score, though no clear dose-response relationship was observed

A mediation analysis of the SUSTAIN 15 trials showed minor contribution of nausea/vomiting to the greater weight reduction during the therapy with once-weekly semaglutide versus its comparators

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A 2023 randomized, phase 2 crossover trial by Hansen et al

As a sodium-glucose cotransporter-2 (SGLT2) inhibitor, it primarily acts on the kidneys by blocking glucose reabsorption, thereby increasing urinary glucose excretion and lowering blood glucose levels in individuals with type 2 diabetes