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The side effect profiles of these two compounds are dramatically different, and for some people, that difference tips the scale
Maintenance and discontinuation SURMOUNT-4, continue vs placebo switch after lead-in to about 20.9% loss: stopping regained about +14% over 52 weeks while continuing lost a further -5.5%
Declining estrogen affects thermoregulation (hot flashes), mood regulation, and even melatonin receptor sensitivity
The bodys natural regulatory mechanisms remain intact while healing processes accelerate
doi:10.1186/s12859-020-03881-z
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