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The theoretical basis seems sound, though comparative data remains limited

Additionally, riboflavin must be transported within cells and into the mitochondria

Medical Conditions Management: Autoimmune diseases like multiple sclerosis benefit from supportive therapy involving regular B12 administration, bolstering immune defenses

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Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects