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In addition to the studies demonstrating the central effects of GLP-1 and its analogs on satiety and reduction of energy intake, there are studies showing other central effects of GLP-1 involving BAT
The molecular mechanisms mediating the actions of metformin on hepatic glucose production remain incompletely understood and are thought to involve engagement of the AMP-activated protein kinase (AMPK) pathway and its upstream kinase, liver kinase B1 (LKB1) [3, 4]
Third, medication is not the whole answer and the data supports this
Statements Author contributions ET and TR wrote the first draft, edited, and wrote the final draft of this article
10.1016/0304-4165(89)90162-1 42 TakahashiT.JaberM
Richardson A, Park WG
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