However, its potential as a CoV vaccine target was largely undermined by early studies of SARS-CoV showing that vaccines expressing N protein did not provide protection and, on the contrary, enhanced infection-induced pneumonia via increased pulmonary eosinophil infiltration and T H 2 cell-biased responses 39,41 , causing ERD
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PMC/NIH
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[PMID: 2459876] PubMed record related to this compound for laboratory literature review
While each has an overall positive safety profile, side effects have been observed