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Unlike the well-characterized cAMP axis, direct evidence describing how GLP-1 receptor agonists modulate Ca 2+ flux within signalosomes remains fragmentary

doi: 10.1073/pnas.1201627109 110 ViljoenE.VisserJ.KoenN.MusekiwaA

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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

Muscle mass plays a major role in metabolic rate, and metabolic rate strongly influences long-term weight stability