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successfully constructed the EcN strain SYNB1618 by inserting the phenylalanine ammonia lyase (PAL) gene, L-amino acid deaminase (LAAD) gene, and high-affinity phenylalanine transporter (PheP) gene into EcN as the chassis bacterium

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The Complete Timeline from FDA Approval to 2026 Sources Conklin KA et al

For sustained energy and metabolic benefits, ongoing monthly injections are typically recommended

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