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DPP-4 inhibitors can on the other hand also be combined with an oral therapy with a SGLT-2 inhibitor (in dual combination when metformin is contraindicated or not tolerated or in triple therapy with metformin)

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NGF levels were also significantly lower in the VPA+LipRSV group compared to the CT group, suggesting that LipRSV treatment may have contributed to a further reduction in NGF levels

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Controlled-release nanocarriers may also support sequential or pulsatile dosing regimens, which could help maintain degradation efficiency over time

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