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The decision to continue, adjust, or discontinue therapy should be based on objective body composition measurements (DEXA scans, circumference measurements), achievement of fat loss goals, tolerance and side effect profile, and physician assessment of metabolic markers

Key treatment options include: Avoidance : Identify and avoid products containing cobalt, such as certain jewellery, cosmetics, and industrial items

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Oral formulations, due to the processes of digestion and absorption, tend to have a slower and potentially less predictable onset, depending on the specific formulation and individual physiology

The molecule was developed by the Australian pharmaceutical company Metabolic Pharmaceuticals (in collaboration with Monash University) and advanced through Phase I safety trials and a Phase IIb obesity efficacy trial enrolling approximately 900 participants in total

2012 Feb;42(1):71-8