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Insulin signaling directly influences immune cell metabolism, macrophage polarization, and T-cell differentiation, thereby shaping inflammatory responses within musculoskeletal tissues ( Increasing evidence from immunometabolic research supports a bidirectional relationship between metabolic dysfunction and inflammatory arthritis, whereby chronic inflammation promotes insulin resistance, which in turn amplifies synovial and entheseal inflammation ( Figure 1 , insulin resistance, adipose tissue inflammation, and impaired incretin signaling converge at the skinjoint axis to amplify IL-23/IL-17driven immune activation and disease progression

Frequent users remained on the unit 72 h post-dose and left the unit for a minimum of 72 h between sessions

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In STEP 1 (semaglutide 2.4 mg, 1,961 participants), most weight loss occurred by weeks 30 to 40, with the curve flattening after that