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Regarding oral semaglutide, in contrast to what was shown in a recent Italian retrospective study, it was mainly prescribed in patients with a disease duration of more than 10 years [23]
However, the top 20 most statistically significantly regulated brain regions in response to treatment were analysed as previously described 37
They include megaloblastic anemia, lethargy, failure to thrive, microcephaly, brain abnormalities, developmental delay, intellectual deficit, seizures, and retinopathy
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