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In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury
Fang C, Ning B, Waqar AB, Niimi M, Li S, Satoh K, Fan J
Toda aplicacin es estrictamente experimental
Gene Name: GPX3
In Kerala's tropical, humid climate with high UV exposure, concurrent use of broad-spectrum SPF 50+ UVA/UVB sunscreen is mandatory to prevent photodamage and mitigate PIH risk
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