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Ibuprofen (e.g., Advil, Motrin, Midol, Nurofen, Dalsi, etc.) is one of the most used non-steroidal anti-inflammatory drugs (NSAIDs) globally and is considered an essential medicine by the World Health Organization (Miranda et al., 2021

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To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration

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