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Additionally, the T149M variant is associated with increased T2D risk and has normal surface expression but reduced binding affinity for GLP-1 and Exenatide, as well as reduced cAMP production (Suzuki et al., 2019)

Thus, supplementation of glutathione is logically expected to downregulate melanogenesis and improve melasma

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Integrative methods combining two or more Omics datasets can identify novel associations in DPN, and computational methods can be leveraged to identify drug targets

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