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Furthermore, recombinant LONP1 cleaves serine-rich repeat sequences in c-MYC, disabling its DNA-binding domain and C-terminal MAX-binding site, thereby exerting anticancer effects [164]
By blocking NNMT, 5-amino-1MQ restores optimal NAD+ and SAM levels, improving cellular function before any external changes become visible
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However, persistently elevated Fe 2 + levels can trigger the Fenton reaction, in which Fe 2 + reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals, leading to the accumulation of reactive oxygen species (ROS) and enhanced lipid peroxidation (11)
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