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Acknowledgments The authors would like to thank Aouatef Bellamine, for her help with study management and Suzanne Morris, at Concrete Medical Writing, LLC, for providing medical writing support (funded by Lonza)

The commercial Fe 3 O 4 nanoparticles, the carbon supports (C) synthesized via the similar process without Hb, the porous carbon supports (pC) obtained using bull serum albumin (BSA) as template and the heme-derived single-atom Fe-N 4 catalysts through pyrolysis (FeSAN) were synthesized as references (Supplementary Figs

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