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These mechanisms are complementary rather than competitive, potentially making combination use attractive for anti-aging focused researchers

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

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While studies explore its potential for skin rejuvenation and tissue repair, there are no established safe or effective dosages for human injection

These compounds work through independent mechanisms, which means they can potentially be used together under physician supervision without pharmacological conflict

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