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Park JJ, Gao B, Beecroft C, Wilkinson KJ, Parsonson A, Zhang K, Yan X, Wang N (2024) Safety and efficacy of JSKN003 in patients with advanced/metastatic solid tumors: A first-in-human, dose-escalation, multicenter, open-label, phase I study

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As creatinine is a breakdown product of creatine phosphate, reduced levels suggest rapid depletion of muscle energy stores during seizures, consistent with increased overall energy demand 34

This breakthrough led to the creation of Melanotan 1, a synthetic analog of the naturally occurring a-Melanocyte-Stimulating-Hormone (a-MSH)

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Tan HK, Yates E, Lilly K, Dhanda AD