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In a high-fat diet (HFD) mouse model, right ventricular function was partly improved by NO 2 -OA reduction of pulmonary arterial remodeling 21

In human umbilical vein endothelial cells (HUVECs), the upregulation of Nox2 expression by AGE-RAGE increased ROS levels, which promoted PXDN and hypochlorous acid (HOCl) expression

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It is greatly expressed in most breast cancer cells (247)

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Counsel patients to report symptoms of thyroid tumors (e.g., a lump in the neck, hoarseness, dysphagia or dyspnea) to their physician [see Boxed Warning, Warnings and Precautions (5.1)]