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69 Conversely, the extracellular release of decorin (DCN, an extracellular matrix-derived damage-associated signaling proteoglycan), 70 high mobility group box 1 (HMGB1, an architectural DNA-binding factor in the cell nucleus), 71 and nuclear receptor coactivator 4 (NCOA4, a mediator of ferritinophagy) 72,73 may function as damage-associated alarm signals that promote inflammatory responses in the local microenvironment

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Hong SJ, Lee JY, Lee DH, Sohn WM, Cho SY

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

J.et al (2018)

The ALP activity was determined by enzymatic colorimetric test 23