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Before initiating therapy, clinicians should assess baseline factors including HbA1c, weight, blood pressure, renal function, and cardiovascular history

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1,005 patients reported weight data, with the median weight of 96.16 kg

GLP-1s (full name: glucagon-like peptide-1 receptor agonists, or GLP-1 agonists) help the pancreas release insulin, reduce blood sugar, slow the rate of stomach emptying, and increase feelings of fullness, explains Gretchen Zimmermann, RD, a registered dietitian specializing in obesity and vice president of clinical strategy at Vida Health

Perhaps most encouraging, 90% of participants who were slow responders, those who had not lost 5% by week 12, went on to achieve clinically meaningful weight loss by week 72

For up to 10% of people, constipation persists throughout treatment at the higher maintenance dose