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Since tirzepatide mimics these two hormones, clinical trials suggest this medication is a useful tool for weight management and to combat insulin resistance, two very common problems for people with PCOS

A study from the Netherlands found the 25th to 75th percentile among people 65 to be 180 to 300 nmol/l (van Wijngaarden, 2017)

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Neither compound significantly affects FSH, LH, PRL, or TSH, further supporting genuine selectivity for the somatotroph GH-releasing axis

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The public comment period for this proposal closes June 29, 2026, with a final FDA determination expected to follow