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4 A history of gallbladder disease A 2022 systematic review of 76 randomised trials found that GLP-1 medications are associated with a relative risk of around 37% for gallbladder or biliary disease, with a higher relative risk in weight-loss trials than in diabetes trials

3 / 13 A lack of B12 may lead to depression, confusion, memory problems, and dementia

B12 helps form red blood cells, which are essential for delivering oxygen to muscles during physical activity

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The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input

While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort