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To elucidate the specific stage of PNT where METTL3 exerts its effects, we introduced STM2457 treatment at various stages of PNT and observed a promotional effect across all periods (Fig
R.LazarenkoO
Using single-sample GSEA, we assigned each patient an OxPhos score using the Molecular Signatures Database (MSigDB) Hallmarks Oxidative Phosphorylation signature 39,40 and then split patients based on the cohort mean (Fig
The timeline can vary depending on factors such as diet, lifestyle, sun exposure, and overall skincare routine
Organoids and engineered tissues can improve control, but they still require validation against human myocardium
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