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Of note, glomerular hyperfiltration could be exacerbated by other hormonal changes associated with scarce glucose control, such as high glucagon levels [49, 51]
J Clin Endocrinol Metab 2019;104:2463-72.ArticlePubMed 43
Assuming that phase IIa trials provide encouraging results, subsequent phase IIb and phase III studies should focus on confirming therapeutic dose, verifying clinical efficacy via histology and assessing long-term clinical outcomes of NASH patients
Its also FDA-approved for reducing cardiovascular risks in adults with type 2 diabetes and heart disease, offering a holistic approach to health management
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