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The following is a review of the preclinical and clinical studies examining the role of GLP-1R agonists on the vascular endothelium and HFpEF: Data from preclinical studies In a study on non-diabetic mice models with arterial hypertension (simulating preconditions for HFpEF), Liraglutide treatment improved blood pressure and cardiac hypertrophy in angiotensin II-induced arterial hypertension independent of glucose/insulin modulation leading to the reversal of cardiac hypertrophy

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The resultant glucose regulatory effect of magnesium and insulin could also be responsible for the recovery in body weight of these treatment groups (magnesium and insulin) compared to diabetic untreated animals that had a progressive and significant reduction in body weight considering their initial values (Table 1)

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