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TRT may also slightly improve baseline metabolic rate, which can enhance the weight loss response to GLP-1 agents by 510% in some studies, though individual variation is substantial

Those on higher doses (1.7 mg and 2.4 mg) lost 12.1%, nearly 3% more

It is noteworthy that the majority of these gastrointestinal manifestations are of a mild nature and predominantly occur during the titration phase (108)

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Start tirzepatide first, stabilize at your maintenance dose over 812 weeks, then introduce NAD+ supplementation at 300mg daily